Revisiting the serum level of anti-Müllerian hormone in patients with functional hypothalamic anovulation

Abstract STUDY QUESTION Are serum levels of anti-Müllerian hormone (AMH) normal in patients with functional hypothalamic anovulation (FHA)? SUMMARY ANSWER Our study confirms that the general FHA population, AMH are not decreased, but if polycystic ovarian morphology (PCOM) excluded, become significantly lower, as other situations gonadotropic insufficiency. WHAT IS KNOWN ALREADY In most low LH (physiological, pharmacological or pathological), low. However, paradoxically, many publications have reported even increased patients. DESIGN, SIZE, DURATION Retrospective observational conducted an academic centre. The data concerning population was collected between 2006 and 2015 from a database including clinical, biological ultrasound information. PARTICIPANTS/MATERIALS, SETTING, METHODS A total 45 were compared to 37 controls matched based on age body mass index (BMI). Serum LH, FSH, androstenedione, testosterone, prolactin measured by immunoassay. We defined PCOM strict criteria: follicle number per ovary (FNPO) ? 12 19 ovary, depending date which assessment carried out device. An level 35 pmol/l could be substitute for excess FNPO. Controls meeting these criteria included this study. MAIN RESULTS AND THE ROLE OF CHANCE There no significant difference ranges controls. Using define status, 46.7% had PCOM. After excluding patients, lower (P < 0.002) Within group, higher ranks BMI than those without within PCOM+ subgroup, FSH still 0.0001, <0.002 <0.05, respectively). positive correlation group. PCOM+, there strong LH. LIMITATIONS, REASONS FOR CAUTION This is retrospective study; our did represent they recruited ART centre; we used modified classification using count and/or in-house thresholds excess; assay longer commercially available. WIDER IMPLICATIONS FINDINGS Besides biasing results presence despite gonadotropin androgen raises issue epigenetically acquired amplification sensitivity granulosa cells ovaries. terms clinical practice, it seems important diagnose reserve too quickly basis decreased alone. On contrary, high context menstrual disorder should lead misdiagnosis syndrome (PCOS) basal FUNDING/COMPETING INTEREST(S) None TRIAL REGISTRATION NUMBER N/A